CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.1270 | Substrate Binding Domain Of Dnak; Chain:A; Domain 2 |
|
1.20.1270.50 | Glycoside hydrolase family 38, central domain |
Domain Context
CATH Clusters
| Superfamily | Glycoside hydrolase family 38, central domain |
| Functional Family | Alpha-mannosidase |
Enzyme Information
| 3.2.1.114 |
Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase.
based on mapping to UniProt Q24451
Man(5)GlcNAc(3)-[protein] + 2 H(2)O = Man(3)GlcNAc(3)-[protein] + 2 alpha-D-mannopyranose.
-!- The enzyme, found in plants and animals, participates in the processing of N-glycans in the Golgi apparatus. -!- It removes two mannosyl residues, one linked by alpha-1,3 linkage, and the other linked by alpha-1,6 linkage, both of which are removed by the same catalytic site. -!- The enzyme is sensitive to swainsonine.
|
UniProtKB Entries (1)
| Q24451 |
MAN2_DROME
Drosophila melanogaster
Alpha-mannosidase 2
|
PDB Structure
| PDB | 1TQS |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Drosophila |
| Primary Citation |
Crystallographic analysis of the interactions of Drosophila melanogaster Golgi alpha-mannosidase II with the naturally occurring glycomimetic salacinol and its analogues
Tetrahedron Asymmetry
|
