CATH Domain 1tk7A01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.20	Single Sheet
	2.20.70	Ubiquitin Ligase Nedd4; Chain: W;
	2.20.70.10

Domain Context

CATH Clusters

Superfamily	2.20.70.10
Functional Family

Enzyme Information

2.3.2.26

HECT-type E3 ubiquitin transferase.

based on mapping to UniProt Q9Y0H4

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)- ubiquitinyl-[acceptor protein]-L-lysine.

-!- In the first step the enzyme transfers ubiquitin from the E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) to a cysteine residue in its HECT domain (which is located in the C-terminal region), forming a thioester bond. -!- In a subsequent step the enzyme transfers the ubiquitin to an acceptor protein, resulting in the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin and the epsilon- amino group of an L-lysine residue of the acceptor protein. -!- Cf. EC 2.3.2.27 and EC 2.3.2.31.

UniProtKB Entries (1)

Q9Y0H4

SUDX_DROME

Drosophila melanogaster

E3 ubiquitin-protein ligase Su(dx)

PDB Structure

PDB	1TK7
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism	Escherichia
Primary Citation	The structure and dynamics of tandem WW domains in a negative regulator of notch signaling, Suppressor of deltex Fedoroff, O.Y., Townson, S.A., Golovanov, A.P., Baron, M., Avis, J.M. J.Biol.Chem.

Network disruptions