CATH Domain 1thzA03

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.140	Cytidine Deaminase; domain 2
	3.40.140.20	AICAR transformylase, duplication domain

Domain Context

CATH Clusters

Superfamily	3.40.140.20
Functional Family	Bifunctional purine biosynthesis protein

Enzyme Information

3.5.4.10	IMP cyclohydrolase. based on mapping to UniProt P31335 IMP + H(2)O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
2.1.2.3	Phosphoribosylaminoimidazolecarboxamide formyltransferase. based on mapping to UniProt P31335 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide.

UniProtKB Entries (1)

PUR9_CHICK

Gallus gallus

Bifunctional purine biosynthesis protein PURH

PDB Structure

PDB	1THZ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening. Xu, L., Li, C., Olson, A.J., Wilson, I.A. J.Biol.Chem.