CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.387 | Viral Envelope Glycoprotein; domain 3 |
|
3.30.387.10 | Viral Envelope Glycoprotein, domain 3 |
Domain Context
CATH Clusters
| Superfamily | Viral Envelope Glycoprotein, domain 3 |
| Functional Family | Envelope glycoprotein |
Enzyme Information
| 3.4.21.91 |
Flavivirin.
based on mapping to UniProt P27914
Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala.
|
| 3.6.1.15 |
Nucleoside-triphosphate phosphatase.
based on mapping to UniProt P27914
NTP + H(2)O = NDP + phosphate.
-!- The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria. -!- Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD. -!- The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
|
| 3.6.4.13 |
RNA helicase.
based on mapping to UniProt P27914
ATP + H(2)O = ADP + phosphate.
-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).
|
UniProtKB Entries (1)
| P27914 |
POLG_DEN2T
Dengue virus 2 Tonga/EKB194/1974
Genome polyprotein
|
PDB Structure
| PDB | 1TG8 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Drosophila |
| Primary Citation |
Conformational changes of the flavivirus e glycoprotein
Structure
|