CATH Classification

Domain Context

CATH Clusters

Superfamily 2.170.230.10
Functional Family

Enzyme Information

3.4.21.89
Signal peptidase I.
based on mapping to UniProt P00803
Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.
-!- Unaffected by inhibitors of most serine peptidases, but site-directed mutagenesis implicates a Ser/Lys catalytic dyad in activity. -!- Cleaves a single bond -Ala-|-Ala- in M13 phage procoat protein, producing free signal peptide and coat protein. -!- Eukaryote signal peptidases that may have somewhat different specificity are known from the endoplasmic reticulum membrane and mitochondrial inner membrane. -!- Belongs to peptidase family S26. -!- Formerly EC 3.4.99.36.

UniProtKB Entries (1)

P00803
LEP_ECOLI
Escherichia coli K-12
Signal peptidase I

PDB Structure

PDB 1T7D
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystallographic and Biophysical Analysis of a Bacterial Signal Peptidase in Complex with a Lipopeptide Based Inhibitor.
Paetzel, M., Goodall, J.J., Kania, M., Dalbey, R.E., Page, M.G.P.
J.Biol.Chem.