CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.80 | Lysozyme-like |
|
3.40.80.10 | Peptidoglycan recognition protein-like |
Domain Context
CATH Clusters
| Superfamily | Peptidoglycan recognition protein-like |
| Functional Family | Peptidoglycan recognition protein 1 |
Enzyme Information
| 3.4.17.13 |
Muramoyltetrapeptide carboxypeptidase.
based on mapping to UniProt Q9VYX7
GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelyl-D-alanine + H(2)O = GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelate + D-alanine.
-!- Variants are known from various microorganisms. -!- Involved in peptidoglycan synthesis, catalyzing both decarboxylation and transpeptidation. -!- Stimulated by divalent cations such as magnesium and calcium, but not zinc. -!- Inhibited by thiol-blocking reagents, but unaffected by penicillin.
|
UniProtKB Entries (1)
| Q9VYX7 |
PGPSA_DROME
Drosophila melanogaster
Peptidoglycan-recognition protein SA
|
PDB Structure
| PDB | 1SXR |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Drosophila |
| Primary Citation |
Crystal structure of the Drosophila peptidoglycan recognition protein (PGRP)-SA at 1.56 A resolution
J.Mol.Biol.
|