CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt Q08881
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q08881
ITK_HUMAN
Homo sapiens
Tyrosine-protein kinase ITK/TSK

PDB Structure

PDB 1SM2
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structures of interleukin-2 tyrosine kinase and their implications for the design of selective inhibitors.
Brown, K., Long, J.M., Vial, S.C., Dedi, N., Dunster, N.J., Renwick, S.B., Tanner, A.J., Frantz, J.D., Fleming, M.A., Cheetham, G.M.
J.Biol.Chem.