CATH Classification

Domain Context

CATH Clusters

Superfamily Serine-tRNA synthetase, tRNA binding domain
Functional Family

Enzyme Information

6.1.1.11
Serine--tRNA ligase.
based on mapping to UniProt P34945
(1) ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). (2) ATP + L-serine + tRNA(Sec) = AMP + diphosphate + L-seryl-tRNA(Sec).
-!- This enzyme also recognizes tRNA(Sec), the special tRNA for selenocysteine, and catalyzes the formation of L-seryl-tRNA(Sec), the substrate for EC 2.9.1.1.

UniProtKB Entries (1)

P34945
SYS_THET2
Thermus thermophilus HB27
Serine--tRNA ligase

PDB Structure

PDB 1SES
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures at 2.5 angstrom resolution of seryl-tRNA synthetase complexed with two analogs of seryl adenylate.
Belrhali, H., Yaremchuk, A., Tukalo, M., Larsen, K., Berthet-Colominas, C., Leberman, R., Beijer, B., Sproat, B., Als-Nielsen, J., Grubel, G., Legrand, J.-F., Lehmann, M., Cusack, S.
Science