CATH Classification

Domain Context

CATH Clusters

Superfamily Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2
Functional Family Receptor protein-tyrosine kinase

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P04626
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q7Z3Y4
Q7Z3Y4_HUMAN
Homo sapiens
Uncharacterized protein

PDB Structure

PDB 1S78
External Links
Method X-RAY DIFFRACTION
Organism Cricetulus
Primary Citation
Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex.
Franklin, M.C., Carey, K.D., Vajdos, F.F., Leahy, D.J., De Vos, A.M., Sliwkowski, M.X.
Cancer Cell