CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Transitional endoplasmic reticulum ATPase

Enzyme Information

3.6.4.6
Vesicle-fusing ATPase.
based on mapping to UniProt Q01853
ATP + H(2)O = ADP + phosphate.
-!- A large family of ATP-hydrolyzing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. -!- They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily. -!- They include peroxin, which apparently is involved in Zellweger's syndrome.

UniProtKB Entries (2)

O35987
NSF1C_RAT
Rattus norvegicus
NSFL1 cofactor p47
Q01853
TERA_MOUSE
Mus musculus
Transitional endoplasmic reticulum ATPase

PDB Structure

PDB 1S3S
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural basis of the interaction between the AAA ATPase p97/VCP and its adaptor protein p47.
Dreveny, I., Kondo, H., Uchiyama, K., Shaw, A., Zhang, X., Freemont, P.S.
Embo J.