CATH Domain 1rwpB00
based on mapping to UniProt P29466
Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-.
-!- Part of the family of inflammatory-caspases, which also includes caspase-4 (EC 22.214.171.124) and caspase-5 (EC 126.96.36.199) in humans and caspase-11 (EC 188.8.131.52), caspase-12, caspase-13 and caspase-14 in mice. -!- Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation. -!- Cleaves pro-interleukin-1-beta (pro-IL-1-beta) to form mature IL-1- beta, a potent mediator of inflammation. -!- Also activates the proinflammatory cytokine, IL-18, which is also known as interferon-gamma-inducing factor. -!- Inhibited by Ac-Tyr-Val-Ala-Asp-CHO. -!- Caspase-11 plays a critical role in the activation of caspase-1 in mice whereas caspase-4 enhances its activation in humans. -!- Belongs to peptidase family C14.
UniProtKB Entries (1)
Structural analysis of caspase-1 inhibitors derived from Tethering.