CATH Domain 1rw8A02
|1.10.510||Transferase(Phosphotransferase); domain 1|
|1.10.510.10||Transferase(Phosphotransferase) domain 1|
|Superfamily||Transferase(Phosphotransferase) domain 1|
|Functional Family||Receptor protein serine/threonine kinase|
Receptor protein serine/threonine kinase.
based on mapping to UniProt P36897
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
-!- The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. -!- Signaling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. -!- Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates. -!- Formerly EC 188.8.131.52.
UniProtKB Entries (1)
TGF-beta receptor type-1
Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain.