CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Receptor protein serine/threonine kinase

Enzyme Information
Receptor protein serine/threonine kinase.
based on mapping to UniProt P36897
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
-!- The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. -!- Signaling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. -!- Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates. -!- Formerly EC

UniProtKB Entries (1)

Homo sapiens
TGF-beta receptor type-1

PDB Structure

External Links
Organism Spodoptera
Primary Citation
Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain.
Sawyer, J.S., Beight, D.W., Britt, K.S., Anderson, B.D., Campbell, R.M., Goodson Jr., T., Herron, D.K., Li, H.Y., McMillen, W.T., Mort, N., Parsons, S., Smith, E.C., Wagner, J.R., Yan, L., Zhang, F., Yingling, J.M.