CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.780.20
Functional Family

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt P20703
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

P20703
UVSW_BPT4
Escherichia virus T4
ATP-dependent DNA helicase uvsW

PDB Structure

PDB 1RIF
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The Crystal Structure of the UvsW Helicase from Bacteriophage T4.
Sickmier, E.A., Kreuzer, K.N., White, S.W.
Structure