CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1820 | alpha/beta hydrolase |
Domain Context
CATH Clusters
| Superfamily | alpha/beta hydrolase |
| Functional Family | Dipeptidyl peptidase 4 |
Enzyme Information
| 3.4.14.5 |
Dipeptidyl-peptidase IV.
based on mapping to UniProt P27487
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
-!- A membrane-bound serine-type peptidase in mammals. -!- EC 3.4.14.11 catalyzes a similar reaction. -!- Belongs to peptidase family S9B.
|
UniProtKB Entries (2)
| Q9XSW6 |
NPY_MACMU
Macaca mulatta
Pro-neuropeptide Y
|
| P27487 |
DPP4_HUMAN
Homo sapiens
Dipeptidyl peptidase 4
|
PDB Structure
| PDB | 1R9N |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Spodoptera |
| Primary Citation |
Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formation.
Protein Sci.
|
