CATH Domain 1r8cA01
|1.10.1410||Poly(a)-polymerase, middle domain|
|1.10.1410.30||CCA tRNA nucleotidyltransferase, domain 2|
|Superfamily||CCA tRNA nucleotidyltransferase, domain 2|
CCA tRNA nucleotidyltransferase.
based on mapping to UniProt O28126
A tRNA precursor + 2 CTP + ATP = a tRNA with a 3' CCA end + 3 diphosphate.
-!- The acylation of all tRNAs with an amino acid occurs at the terminal ribose of a 3' CCA sequence. -!- The CCA sequence is added to the tRNA precursor by stepwise nucleotide addition performed by a single enzyme that is ubiquitous in all living organisms. -!- Although the enzyme has the option of releasing the product after each addition, it prefers to stay bound to the product and proceed with the next addition. -!- Formerly EC 184.108.40.206 and EC 220.127.116.11.
UniProtKB Entries (1)
Archaeoglobus fulgidus DSM 4304
Crystal structures of an archaeal class I CCA-adding enzyme and its nucleotide complexes