CATH Domain 1r7rA05

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.300	P-loop containing nucleotide triphosphate hydrolases

Domain Context

CATH Clusters

Superfamily	P-loop containing nucleotide triphosphate hydrolases
Functional Family	Transitional endoplasmic reticulum ATPase

Enzyme Information

3.6.4.6

Vesicle-fusing ATPase.

based on mapping to UniProt Q01853

ATP + H(2)O = ADP + phosphate.

-!- A large family of ATP-hydrolyzing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. -!- They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily. -!- They include peroxin, which apparently is involved in Zellweger's syndrome.

UniProtKB Entries (1)

Q01853

TERA_MOUSE

Mus musculus

Transitional endoplasmic reticulum ATPase

PDB Structure

PDB	1R7R
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	The crystal structure of murine p97/VCP at 3.6A Huyton, T., Pye, V.E., Briggs, L.C., Flynn, T.C., Beuron, F., Kondo, H., Ma, J., Zhang, X., Freemont, P.S. J.Struct.Biol.