CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Bifunctional pinoresinol-lariciresinol reductase 1 |
Enzyme Information
| 1.23.1.3 |
(-)-pinoresinol reductase.
based on mapping to UniProt Q9LD14
(-)-lariciresinol + NADP(+) = (-)-pinoresinol + NADPH.
-!- The reaction is catalyzed in vivo in the opposite direction to that shown. -!- A multifunctional enzyme that usually further reduces the product to (+)-secoisolariciresinol (EC 1.23.1.4). -!- Isolated from the plants Thuja plicata (western red cedar), Linum perenne (perennial flax) and Arabidopsis thaliana (thale cress).
|
| 1.23.1.4 |
(-)-lariciresinol reductase.
based on mapping to UniProt Q9LD14
(+)-secoisolariciresinol + NADP(+) = (-)-lariciresinol + NADPH.
-!- The reaction is catalyzed in vivo in the opposite direction to that shown. -!- A multifunctional enzyme that also reduces (-)-pinoresinol (EC 1.23.1.3). -!- Isolated from the plants Thuja plicata (western red cedar) and Linum corymbulosum.
|
| 1.23.1.1 |
(+)-pinoresinol reductase.
based on mapping to UniProt Q9LD14
(+)-lariciresinol + NADP(+) = (+)-pinoresinol + NADPH.
-!- The reaction is catalyzed in vivo in the opposite direction to that shown. -!- A multifunctional enzyme that further reduces the product to the lignan (-)-secoisolariciresinol (EC 1.23.1.2). -!- Isolated from the plants Forsythia intermedia, Thuja plicata (western red cedar), Linum perenne (perennial flax) and Linum corymbulosum. -!- The 4-pro-R hydrogen of NADH is transferred to the 7-pro-R position of lariciresinol.
|
UniProtKB Entries (1)
| Q9LD14 |
PILR1_THUPL
Thuja plicata
Bifunctional pinoresinol-lariciresinol reductase 1
|
PDB Structure
| PDB | |
| External Links | |
| Method | |
| Organism | |
| Primary Citation |
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