CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.180 | Quinone Oxidoreductase; Chain A, domain 1 |
|
3.90.180.10 | Medium-chain alcohol dehydrogenases, catalytic domain |
Domain Context
CATH Clusters
| Superfamily | Medium-chain alcohol dehydrogenases, catalytic domain |
| Functional Family | Quinone oxidoreductase 1 |
Enzyme Information
| 1.6.5.5 |
NADPH:quinone reductase.
based on mapping to UniProt P28304
NADPH + 2 quinone = NADP(+) + 2 semiquinone.
-!- Specific for NADPH. -!- Catalyzes the one-electron reduction of certain quinones, with the orthoquinones 1,2-naphthoquinone and 9,10-phenanthrenequinone being the best substrates. -!- Dicoumarol (cf. EC 1.6.5.2) and nitrofurantoin are competitive inhibitors with respect to the quinone substrate. -!- The semiquinone free-radical product may be non-enzymically reduced to the hydroquinone or oxidized back to quinone in the presence of O(2). -!- Abundant in the lens of the eye of some mammalian species.
|
UniProtKB Entries (1)
| P28304 |
QOR1_ECOLI
Escherichia coli K-12
Quinone oxidoreductase 1
|
PDB Structure
| PDB | 1QOR |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of Escherichia coli QOR quinone oxidoreductase complexed with NADPH.
J.Mol.Biol.
|
