CATH Domain 1qlhA01
|3.90.180||Quinone Oxidoreductase; Chain A, domain 1|
|220.127.116.11||Medium-chain alcohol dehydrogenases, catalytic domain|
|Superfamily||Medium-chain alcohol dehydrogenases, catalytic domain|
|Functional Family||S-(hydroxymethyl)glutathione dehydrogenase|
based on mapping to UniProt P00327
(1) A primary alcohol + NAD(+) = an aldehyde + NADH. (2) A secondary alcohol + NAD(+) = a ketone + NADH.
-!- Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol. -!- The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.
UniProtKB Entries (1)
Alcohol dehydrogenase E chain
Substitutions in the Flexible Loop of Horse Liver Alcohol Dehydrogenase Hinder the Conformational Change and Unmask Hydrogen Transfer