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1 keywords

CATH Domain 1qaxB02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.90 Alpha-Beta Complex
Topology 3.90.770 3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2
Homologous Superfamily 3.90.770.10 3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2

Domain Context

CATH Clusters

Superfamily 3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2
Functional Family

Enzyme Information

1.1.1.88
Hydroxymethylglutaryl-CoA reductase.
based on mapping to UniProt P13702
(R)-mevalonate + CoA + 2 NAD(+) = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH.

UniProtKB Entries (1)

P13702
MVAA_PSEMV
Pseudomonas mevalonii
3-hydroxy-3-methylglutaryl-coenzyme A reductase

PDB Structure

PDB 1QAX
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Substrate-induced closure of the flap domain in the ternary complex structures provides insights into the mechanism of catalysis by 3-hydroxy-3-methylglutaryl-CoA reductase.
Tabernero, L., Bochar, D.A., Rodwell, V.W., Stauffacher, C.V.
Proc.Natl.Acad.Sci.USA
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