CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family

Enzyme Information

2.7.7.-
Nucleotidyltransferases.
based on mapping to UniProt P03692
3.6.4.12
DNA helicase.
based on mapping to UniProt P03692
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

P03692
PRIM_BPT7
Enterobacteria phage T7
DNA primase/helicase

PDB Structure

PDB 1Q57
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The Crystal Structure of the Bifunctional Primase-Helicase of Bacteriophage T7
Toth, E.A., Li, Y., Sawaya, M.R., Cheng, Y., Ellenberger, T.
Mol.Cell