CATH Domain 1pl0D01

×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.287	Helix Hairpins
	1.10.287.440

Domain Context

CATH Clusters

Superfamily	1.10.287.440
Functional Family	Bifunctional purine biosynthesis protein PURH

Enzyme Information

2.1.2.3	Phosphoribosylaminoimidazolecarboxamide formyltransferase. based on mapping to UniProt P31939 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide.
3.5.4.10	IMP cyclohydrolase. based on mapping to UniProt P31939 IMP + H(2)O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.

UniProtKB Entries (1)

PUR9_HUMAN

Homo sapiens

Bifunctional purine biosynthesis protein PURH

PDB Structure

PDB	1PL0
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal Structures of Human Bifunctional Enzyme Aminoimidazole-4-carboxamide Ribonucleotide Transformylase/IMP Cyclohydrolase in Complex with Potent Sulfonyl-containing Antifolates. Cheong, C.G., Wolan, D.W., Greasley, S.E., Horton, P.A., Beardsley, G.P., Wilson, I.A. J.Biol.Chem.