CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | 6-phosphogluconate dehydrogenase, decarboxylating |
Enzyme Information
| 1.1.1.44 |
Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating).
based on mapping to UniProt P00349
6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH.
-!- The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce NADPH and pentose for biosynthetic reactions. -!- Highly specific for NADP(+). -!- Cf. EC 1.1.1.343.
|
UniProtKB Entries (1)
| P00349 |
6PGD_SHEEP
Ovis aries
6-phosphogluconate dehydrogenase, decarboxylating
|
PDB Structure
| PDB | 1PGN |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystallographic study of coenzyme, coenzyme analogue and substrate binding in 6-phosphogluconate dehydrogenase: implications for NADP specificity and the enzyme mechanism.
Structure
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