CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family

Enzyme Information

2.7.1.21
Thymidine kinase.
based on mapping to UniProt P24425
ATP + thymidine = ADP + thymidine 5'-phosphate.
-!- Deoxyuridine can also act as acceptor. -!- dGTP can also act as donor. -!- The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyzes this reaction as well as those of EC 2.7.1.114, EC 2.7.1.118 and EC 2.7.4.9. -!- Formerly EC 2.7.1.75.

UniProtKB Entries (1)

P24425
KITH_EHV4
Equine herpesvirus type 4 (strain 1942)
Thymidine kinase

PDB Structure

PDB 1P73
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases.
Gardberg, A., Shuvalova, L., Monnerjahn, C., Konrad, M., Lavie, A.
Structure