CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.970
Functional Family Acetolactate synthase

Enzyme Information

2.2.1.6
Acetolactate synthase.
based on mapping to UniProt P27696
2 pyruvate = 2-acetolactate + CO(2).
-!- The reaction shown is in the pathway of biosynthesis of valine. -!- The enzyme can also transfer the acetaldehyde from pyruvate to 2-oxobutanoate, forming 2-ethyl-2-hydroxy-3-oxobutanoate, also known as 2-aceto-2-hydroxybutanoate, a reaction in the biosynthesis of isoleucine. -!- Formerly EC 4.1.3.18.

UniProtKB Entries (1)

P27696
ILVB_KLEPN
Klebsiella pneumoniae
Acetolactate synthase, catabolic

PDB Structure

PDB 1OZH
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The Crystal Structures of Klebsiella pneumoniae Acetolactate Synthase with Enzyme-bound Cofactor and with an Unusual Intermediate.
Pang, S.S., Duggleby, R.G., Schowen, R.L., Guddat, L.W.
J.Biol.Chem.