CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleoside phosphorylase domain
Functional Family Purine nucleoside phosphorylase DeoD-type

Enzyme Information

2.4.2.1
Purine-nucleoside phosphorylase.
based on mapping to UniProt P0ABP8
(1) Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. (2) Purine deoxynucleoside + phosphate = purine + 2'-deoxy-alpha-D-ribose 1-phosphate.
-!- Specificity not completely determined. -!- Can also catalyze ribosyltransferase reactions of the type catalyzed by EC 2.4.2.5.

UniProtKB Entries (1)

P0ABP8
DEOD_ECOLI
Escherichia coli K-12
Purine nucleoside phosphorylase DeoD-type

PDB Structure

PDB 1OV6
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Designer gene therapy using an Escherichia coli purine nucleoside phosphorylase/prodrug system.
Bennett, E.M., Anand, R., Allan, P.W., Hassan, A.E., Hong, J.S., Levasseur, D.N., McPherson, D.T., Parker, W.B., Secrist, J.A., Sorscher, E.J., Townes, T.M., Waud, W.R., Ealick, S.E.
Chem.Biol.