CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family

Enzyme Information

4.1.2.13
Fructose-bisphosphate aldolase.
based on mapping to UniProt P58315
D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.
-!- Also acts on (3S,4R)-ketose 1-phosphates. -!- The enzymes increase electron-attraction by the carbonyl group, some (Class I) forming a protonated imine with it, others (Class II), mainly of microbial origin, polarizing it with a metal ion, e.g. zinc. -!- Formerly EC 4.1.2.7.

UniProtKB Entries (1)

P58315
ALF1_THETK
Thermoproteus tenax Kra 1
Fructose-bisphosphate aldolase class 1

PDB Structure

PDB 1OK6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of an archaeal class I aldolase and the evolution of (betaalpha)8 barrel proteins.
Lorentzen, E., Pohl, E., Zwart, P., Stark, A., Russell, R.B., Knura, T., Hensel, R., Siebers, B.
J. Biol. Chem.