CATH Classification

Domain Context

CATH Clusters

Superfamily 6.10.250.130
Functional Family

Enzyme Information

1.4.3.4
Monoamine oxidase.
based on mapping to UniProt P21396
RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2).
-!- Catalyzes the oxidative deamination of neurotransmitters and biogenic amines. -!- Acts on primary amines, and also on some secondary and tertiary amines. -!- It differs from EC 1.4.3.21, as it can oxidize secondary and tertiary amines but not methylamine. -!- Inhibited by acetylenic compounds such as chlorgyline, 1-deprenyl and pargyline but, unlike EC 1.4.3.21 and EC 1.4.3.22, it is not inhibited by semicarbazide. -!- Formerly EC 1.4.3.9.

UniProtKB Entries (1)

P21396
AOFA_RAT
Rattus norvegicus
Amine oxidase [flavin-containing] A

PDB Structure

PDB 1O5W
External Links
Method X-RAY DIFFRACTION
Organism Saccharomyces
Primary Citation
Structure of rat monoamine oxidase a and its specific recognitions for substrates and inhibitors.
Ma, J., Yoshimura, M., Yamashita, E., Nakagawa, A., Ito, A., Tsukihara, T.
J.Mol.Biol.