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1 keywords

CATH Domain 1nw3A02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.150 Vaccinia Virus protein VP39

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Histone-lysine N-methyltransferase, H3 lysine-79 specific

Enzyme Information

2.1.1.43
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q8TEK3
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

Q8TEK3
DOT1L_HUMAN
Homo sapiens
Histone-lysine N-methyltransferase, H3 lysine-79 specific

PDB Structure

PDB 1NW3
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of the Catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase
Min, J., Feng, Q., Li, Z., Zhang, Y., Xu, R.M.
Cell(Cambridge,Mass.)
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