CATH Classification

Domain Context

CATH Clusters

Superfamily Immunoglobulins
Functional Family Fibroblast growth factor receptor

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P21802
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

O15520
FGF10_HUMAN
Homo sapiens
Fibroblast growth factor 10

PDB Structure

PDB 1NUN
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors.
Yeh, B.K., Igarashi, M., Eliseenkova, A.V., Plotnikov, A.N., Sher, I., Ron, D., Aaronson, S.A., Mohammadi, M.
Proc.Natl.Acad.Sci.USA