CATH Classification

Domain Context

CATH Clusters

Superfamily Herpesvirus/Caudovirus protease domain
Functional Family Capsid scaffolding protein

Enzyme Information

3.4.21.97
Assemblin.
based on mapping to UniProt P16753
Cleaves -Ala-|-Ser- and -Ala-|-Ala- bonds in the scaffold protein.
-!- Involved in the breakdown of the scaffold protein during the late stages of assembly of the herpes-virus virion. -!- Inhibited by diisopropyl fluorophosphate. -!- Belongs to peptidase family S21.

UniProtKB Entries (1)

P16753
SCAF_HCMVA
Human herpesvirus 5 strain AD169
Capsid scaffolding protein

PDB Structure

PDB 1NKK
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural and Biochemical Studies of Inhibitor Binding to Human Cytomegalovirus Protease
Khayat, R., Batra, R., Qian, C., Halmos, T., Bailey, M., Tong, L.
Biochemistry