CATH Classification

Domain Context

CATH Clusters

Superfamily DNA-binding pseudobarrel domain
Functional Family

Enzyme Information

3.1.21.4
Type II site-specific deoxyribonuclease.
based on mapping to UniProt P14633
Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates.
-!- Large group of enzymes which recognize specific short DNA sequences and cleave either within, or at a short specific distance from, the recognition site. -!- See the REBASE database for a complete list of these enzymes: http://rebase.neb.com/rebase/

UniProtKB Entries (1)

P14633
T2E2_ECOLX
Escherichia coli
Type-2 restriction enzyme EcoRII

PDB Structure

PDB 1NA6
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of type IIE restriction endonuclease EcoRII reveals an autoinhibition mechanism by a novel effector-binding fold.
Zhou, X.E., Wang, Y., Reuter, M., Mucke, M., Kruger, D.H., Meehan, E.J., Chen, L.
J.Mol.Biol.