CATH Domain 1n8yC02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.10	Ribbon
	2.10.220	Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2
	2.10.220.10	Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2

Domain Context

CATH Clusters

Superfamily	Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2
Functional Family	Receptor protein-tyrosine kinase

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P06494

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P06494

ERBB2_RAT

Rattus norvegicus

Receptor tyrosine-protein kinase erbB-2

PDB Structure

PDB	1N8Y
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Cricetulus
Primary Citation	Structure of the Extracellular Region of HER2 Alone and in complex with the Herceptin Fab Cho, H.-S., Mason, K., Ramyar, K.X., Stanley, A.M., Gabelli, S.B., Denney Jr., D.W., Leahy, D.J. Nature

Network disruptions