CATH Domain 1n24B02

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CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.600	Farnesyl Diphosphate Synthase
	1.10.600.10	Farnesyl Diphosphate Synthase

Domain Context

CATH Clusters

Superfamily	Farnesyl Diphosphate Synthase
Functional Family	Isoprene synthase, chloroplastic

Enzyme Information

4.2.3.116	(+)-camphene synthase. based on mapping to UniProt O81192 Geranyl diphosphate = (+)-camphene + diphosphate. -!- Cyclase I of Salvia officinalis (sage) gives about equal parts (+)- camphene and (+)-alpha-pinene. -!- (3R)-linalyl diphosphate can also be used by the enzyme in preference to (3S)-linalyl diphosphate. -!- See also EC 4.2.3.121.
4.2.3.121	(+)-alpha-pinene synthase. based on mapping to UniProt O81192 Geranyl diphosphate = (+)-alpha-pinene + diphosphate. -!- Cyclase I of Salvia officinalis (sage) gives about equal parts (+)- alpha-pinene and (+)-camphene, whereas cyclase III gives about equal parts of (+)-alpha-pinene and (+)-beta-pinene. -!- (3R)-linalyl diphosphate can also be used by the enzyme in preference to (3S)-linalyl diphosphate. -!- The 4-pro-R hydrogen of geranyl diphosphate is lost. -!- With synthase II of Pinus taeda (loblolly pine) (+)-beta-pinene was the only product. -!- See also EC 4.2.3.122 and EC 4.2.3.116.
5.5.1.8	(+)-bornyl diphosphate synthase. based on mapping to UniProt O81192 Geranyl diphosphate = (+)-bornyl diphosphate. -!- The enzyme from Salvia officinalis (sage) can also use (3R)-linalyl diphosphate or more slowly neryl diphosphate in vitro. -!- The reaction proceeds via isomeration of geranyl diphosphate to (3R)- linalyl diphosphate. -!- The oxygen and phosphorus originally linked to C-1 of geranyl diphosphate end up linked to C-2 of (+)-bornyl diphosphate. -!- cf. EC 5.5.1.22.

UniProtKB Entries (1)

BPPS_SALOF

Salvia officinalis

(+)-bornyl diphosphate synthase, chloroplastic

PDB Structure

PDB	1N24
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Bornyl diphosphate synthase: Structure and strategy for carbocation manipulation by a terpenoid cyclase Whittington, D.A., Wise, M.L., Urbansky, M., Coates, R.M., Croteau, R.B., Christianson, D.W. Proc.Natl.Acad.Sci.USA