CATH Classification

Domain Context

CATH Clusters

Superfamily Cyclophilin-like
Functional Family Peptidyl-prolyl cis-trans isomerase

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt O43447
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

O43447
PPIH_HUMAN
Homo sapiens
Peptidyl-prolyl cis-trans isomerase H

PDB Structure

PDB 1MZW
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide
Reidt, U., Wahl, M.C., Fasshauer, D., Horowitz, D.S., Luehrmann, R., Ficner, R.
J.Mol.Biol.