CATH Domain 1mx1C00

×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1820	alpha/beta hydrolase

Domain Context

CATH Clusters

Superfamily	alpha/beta hydrolase
Functional Family	Carboxylic ester hydrolase

Enzyme Information

3.1.1.56	Methylumbelliferyl-acetate deacetylase. based on mapping to UniProt P23141 4-methylumbelliferyl acetate + H(2)O = 4-methylumbelliferone + acetate. -!- Acts on short-chain acyl esters of 4-methylumbelliferone, but not on naphthyl, indoxyl or thiocholine esters.
3.1.1.1	Carboxylesterase. based on mapping to UniProt P23141 A carboxylic ester + H(2)O = an alcohol + a carboxylate. -!- Wide specificity; also hydrolyzes vitamin A esters. -!- The enzymes from microsomes also catalyze the reactions of EC 3.1.1.2, EC 3.1.1.5, EC 3.1.1.6, EC 3.1.1.23, EC 3.1.1.28, EC 3.1.2.2, EC 3.5.1.4 and EC 3.5.1.13. -!- Formerly EC 3.1.1.12.

UniProtKB Entries (1)

EST1_HUMAN

Homo sapiens

Liver carboxylesterase 1

PDB Structure

PDB	1MX1
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Spodoptera
Primary Citation	Crystal Structure of Human Carboxylesterase 1 Complexed with the Alzheimer's Drug Tacrine: From Binding Promiscuity to Selective Inhibition Bencharit, S., Morton, C.L., Hyatt, J.L., Kuhn, P., Danks, M.K., Potter, P.M., Redinbo, M.R. CHEM.BIOL.