CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Thymidylate kinase

Enzyme Information

2.7.4.9
dTMP kinase.
based on mapping to UniProt P9WKE1
ATP + dTMP = ADP + dTDP.

UniProtKB Entries (1)

P9WKE1
KTHY_MYCTU
Mycobacterium tuberculosis H37Rv
Thymidylate kinase

PDB Structure

PDB 1MRN
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism.
Haouz, A., Vanheusden, V., Munier-Lehmann, H., Froeyen, M., Herdewijn, P., Van Calenbergh, S., Delarue, M.
J.Biol.Chem.