CATH Classification

Domain Context

CATH Clusters

Superfamily Zinc/RING finger domain, C3HC4 (zinc finger)
Functional Family chromodomain-helicase-DNA-binding protein 4 isoform X1

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt Q14839
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

Q14839
CHD4_HUMAN
Homo sapiens
Chromodomain-helicase-DNA-binding protein 4

PDB Structure

PDB 1MM2
External Links
Method SOLUTION NMR
Organism Escherichia
Primary Citation
Engineering a Protein Scaffold from a PHD Finger
Kwan, A.H.Y., Gell, D.A., Verger, A., Crossley, M., Matthews, J.M., Mackay, J.P.
structure