CATH Classification

Domain Context

CATH Clusters

Superfamily Nitric Oxide Synthase; Chain A, domain 3
Functional Family Nitric oxide synthase, brain

Enzyme Information

1.14.14.47
Nitric-oxide synthase (flavodoxin).
based on mapping to UniProt P0A004
2 L-arginine + 3 reduced flavodoxin + 4 O(2) = 2 L-citrulline + 2 nitric oxide + 3 oxidized flavodoxin + 4 H(2)O.
-!- The enzyme, found in bacteria and archaea, consist of only an oxygenase domain and functions together with bacterial ferredoxins or flavodoxins. -!- The orthologous enzymes from plants and animals also contain a reductase domain and use only NADPH as the electron donor (cf. EC 1.14.13.39). -!- Formerly EC 1.14.13.165.

UniProtKB Entries (1)

P0A004
NOSO_STAAU
Staphylococcus aureus
Nitric oxide synthase oxygenase

PDB Structure

PDB 1MJT
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structure of SANOS, a Bacterial Nitric Oxide Synthase Oxygenase Protein from Staphylococcus aureus
Bird, L.E., Ren, J., Zhang, J., Foxwell, N., Hawkins, A.R., Charles, I.G., Stammers, D.K.
Structure