CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Enoyl-[acyl-carrier-protein] reductase [NADH]

Enzyme Information

1.3.1.9
Enoyl-[acyl-carrier-protein] reductase (NADH).
based on mapping to UniProt P0AEK4
An acyl-[acyl-carrier protein] + NAD(+) = a trans-2,3-dehydroacyl-[acyl- carrier protein] + NADH.
-!- The enzyme catalyzes an essential step in fatty acid biosynthesis, the reduction of the 2,3-double bond in enoyl-acyl-[acyl-carrier- protein] derivatives of the elongating fatty acid moiety. -!- The enzyme from the bacterium Escherichia coli accepts substrates with carbon chain length from 4 to 18. -!- The FAS-I enzyme from the bacterium Mycobacterium tuberculosis prefers substrates with carbon chain length from 12 to 24 carbons.

UniProtKB Entries (1)

P0AEK4
FABI_ECOLI
Escherichia coli K-12
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI

PDB Structure

PDB 1MFP
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Indole Naphthyridinones as Inhibitors of Bacterial Enoyl-ACP Reductases FabI and FabK
Seefeld, M.A., Miller, W.H., Newlander, K.A., Burgess, W.J., DeWolf Jr., W.E., Elkins, P.A., Head, M.S., Jakas, D.R., Janson, C.A., Keller, P.M., Manley, P.J., Moore, T.D., Payne, D.J., Pearson, S., Polizzi, B.J., Qiu, X., Rittenhouse, S.F., Uzinskas, I.N., Wallis, N.G., Huffman, W.F.
J.MED.CHEM.