CATH Classification

Domain Context

CATH Clusters

Superfamily Phospholipase A2 domain
Functional Family Acidic phospholipase A2

Enzyme Information

3.1.1.4
Phospholipase A(2).
based on mapping to UniProt P60045
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
-!- Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position.

UniProtKB Entries (1)

P60045
PA2A3_NAJSG
Naja sagittifera
Acidic phospholipase A2 3

PDB Structure

PDB 1MF4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Design of specific peptide inhibitors for group I phospholipase A2: structure of a complex formed between phospholipase A2 from Naja naja sagittifera (group I) and a designed peptide inhibitor Val-Ala-Phe-Arg-Ser (VAFRS) at 1.9 A resolution reveals unique features
Singh, R.K., Vikram, P., Makker, J., Jabeen, T., Sharma, S., Dey, S., Kaur, P., Srinivasan, A., Singh, T.P.
Biochemistry