CATH Domain 1m04A02

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.379	Chitobiase; domain 2
	3.30.379.10	Chitobiase/beta-hexosaminidase domain 2-like

Domain Context

CATH Clusters

Superfamily	Chitobiase/beta-hexosaminidase domain 2-like
Functional Family

Enzyme Information

UniProtKB Entries (1)

O85361_STRPL

Streptomyces plicatus

B-N-acetylhexosaminidase

PDB Structure

PDB	1M04
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Aspartate 313 in the Streptomyces plicatus hexosaminidase plays a critical role in substrate-assisted catalysis by orienting the 2-acetamido group and stabilizing the transition state. Williams, S.J., Mark, B.L., Vocadlo, D.J., James, M.N., Withers, S.G. J.Biol.Chem.