CATH Classification

Domain Context

CATH Clusters

Superfamily Uracil-DNA glycosylase-like domain
Functional Family Uracil-DNA glycosylase

Enzyme Information

3.2.2.27
Uracil-DNA glycosylase.
based on mapping to UniProt P12295
Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.
-!- Uracil-DNA glycosylases are widespread enzymes that are found in all living organisms. -!- Uracil-DNA glycosylase (EC 3.2.2.27) and double-stranded uracil-DNA glycosylase (EC 3.2.2.28) form a central part of the DNA-repair machinery since they initiate the DNA base-excision repair pathway by hydrolyzing the N-glycosidic bond between uracil and the deoxyribose sugar thereby catalyzing the removal of mis-incorporated uracil from DNA.

UniProtKB Entries (2)

P12295
UNG_ECOLI
Escherichia coli K-12
Uracil-DNA glycosylase
P14739
UNGI_BPPB2
Bacillus phage PBS2
Uracil-DNA glycosylase inhibitor

PDB Structure

PDB 1LQM
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Domain closure and action of uracil DNA glycosylase (UDG): structures of new crystal forms containing the Escherichia coli enzyme and a comparative study of the known structures involving UDG.
Saikrishnan, K., Bidya Sagar, M., Ravishankar, R., Roy, S., Purnapatre, K., Handa, P., Varshney, U., Vijayan, M.
Acta Crystallogr.,Sect.D