CATH Classification

Domain Context

CATH Clusters

Superfamily 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1
Functional Family

Enzyme Information

2.5.1.18
Glutathione transferase.
based on mapping to UniProt Q9I4K6
RX + glutathione = HX + R-S-glutathione.
-!- A group of enzymes of broad specificity. -!- R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. -!- Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange. -!- Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.

UniProtKB Entries (1)

Q9I4K6
FOSA_PSEAE
Pseudomonas aeruginosa PAO1
Glutathione transferase FosA

PDB Structure

PDB 1LQK
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of a genomically encoded fosfomycin resistance protein (FosA) at 1.19 A resolution by MAD phasing off the L-III edge of Tl(+)
Rife, C.L., Pharris, R.E., Newcomer, M.E., Armstrong, R.N.
J.Am.Chem.Soc.