CATH Domain 1loxA01

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CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.245	Lipoxygenase-1; domain 5
	1.20.245.10	Lipoxygenase-1; Domain 5

Domain Context

CATH Clusters

Superfamily	Lipoxygenase-1; Domain 5
Functional Family	Arachidonate 5-lipoxygenase a

Enzyme Information

1.13.11.33	Arachidonate 15-lipoxygenase. based on mapping to UniProt P12530 Arachidonate + O(2) = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa- 5,8,11,13-tetraenoate. -!- The product is rapidly converted to the corresponding 15S-hydroxy compound.
1.13.11.31	Arachidonate 12-lipoxygenase. based on mapping to UniProt P12530 Arachidonate + O(2) = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa- 5,8,10,14-tetraenoate. -!- The product is rapidly reduced to the corresponding 12S-hydroxy compound.

UniProtKB Entries (1)

LOX15_RABIT

Oryctolagus cuniculus

Arachidonate 15-lipoxygenase

PDB Structure

PDB	1LOX
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity. Gillmor, S.A., Villasenor, A., Fletterick, R., Sigal, E., Browner, M.F. Nat.Struct.Biol.