CATH Classification

Domain Context

CATH Clusters

Superfamily Glycosidases
Functional Family Acidic endochitinase SE2

Enzyme Information

3.2.1.14
Chitinase.
based on mapping to UniProt P23472
Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta- linkages in chitin and chitodextrins.
-!- The enzyme binds to chitin and randomly cleaves glycosidic linkages in chitin and chitodextrins in a non-processive mode, generating chitooligosaccharides and free ends on which exo-chitinases and exo- chitodextrinases can act. -!- Activity is greatly stimulated in the presence of EC 1.14.99.53, which attacks the crystalline structure of chitin and makes the polymer more accesible to the chitinase. -!- Cf. EC 3.2.1.202.
3.2.1.17
Lysozyme.
based on mapping to UniProt P23472
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl- D-glucosamine residues in chitodextrins.
-!- Cf. EC 3.2.1.14.

UniProtKB Entries (1)

P23472
CHLY_HEVBR
Hevea brasiliensis
Hevamine-A

PDB Structure

PDB 1LLO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Stereochemistry of chitin hydrolysis by a plant chitinase/lysozyme and X-ray structure of a complex with allosamidin: evidence for substrate assisted catalysis.
Terwisscha van Scheltinga, A.C., Armand, S., Kalk, K.H., Isogai, A., Henrissat, B., Dijkstra, B.W.
Biochemistry