CATH Classification

Domain Context

CATH Clusters

Superfamily Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family

Enzyme Information

2.1.1.45
Thymidylate synthase.
based on mapping to UniProt P00469
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

UniProtKB Entries (1)

P00469
TYSY_LACCA
Lactobacillus casei
Thymidylate synthase

PDB Structure

PDB 1LCA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei.
Finer-Moore, J., Fauman, E.B., Foster, P.G., Perry, K.M., Santi, D.V., Stroud, R.M.
J.Mol.Biol.