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1 keywords

CATH Domain 1l4gA01

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.1610 5,6-Dimethylbenzimidazole Phosphoribosyltransferase; Chain: A; domain 1
Homologous Superfamily 1.10.1610.10 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (CobT), small domain

Domain Context

CATH Clusters

Superfamily 1.10.1610.10
Functional Family Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Enzyme Information

2.4.2.21
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase.
based on mapping to UniProt Q05603
Beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate.
-!- Also acts on benzimidazole, and the clostridial enzyme acts on adenine to form 7-alpha-D-ribosyladenine 5'-phosphate. -!- The product of the reaction, alpha-ribazole 5'-phosphate, forms part of the corrin biosynthesis pathway and is a substrate for EC 2.7.8.2. -!- It can also be dephosphorylated to form alpha-ribazole by the action of EC 3.1.3.73.

UniProtKB Entries (1)

Q05603
COBT_SALTY
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

PDB Structure

PDB 1L4G
External Links
Method X-RAY DIFFRACTION
Organism Salmonella
Primary Citation
Capture of a labile substrate by expulsion of water molecules from the active site of nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) from Salmonella enterica.
Cheong, C.G., Escalante-Semerena, J.C., Rayment, I.
J.Biol.Chem.
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