CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family

Enzyme Information

2.1.1.196
Cobalt-precorrin-6B (C(15))-methyltransferase (decarboxylating).
based on mapping to UniProt O26249
Cobalt-precorrin-6B + S-adenosyl-L-methionine = cobalt-precorrin-7 + S-adenosyl-L-homocysteine + CO(2).
-!- This enzyme catalyzes both methylation at C-15 and decarboxylation of the C-12 acetate side chain of cobalt-precorrin-6B, a step in the anaerobic (early cobalt insertion) adenosylcobalamin biosynthesis pathway.

UniProtKB Entries (1)

O26249
CBIT_METTH
Methanothermobacter thermautotrophicus str. Delta H
Probable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating)

PDB Structure

PDB 1KXZ
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The Crystal Structure of MT0146/CbiT Suggests that the Putative Precorrin-8W Decarboxylase is a Methyltransferase
Keller, J.P., Smith, P.M., Benach, J., Christendat, D., DeTitta, G., Hunt, J.F.
Structure