CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family

Enzyme Information

2.7.1.21
Thymidine kinase.
based on mapping to UniProt P03176
ATP + thymidine = ADP + thymidine 5'-phosphate.
-!- Deoxyuridine can also act as acceptor. -!- dGTP can also act as donor. -!- The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyzes this reaction as well as those of EC 2.7.1.114, EC 2.7.1.118 and EC 2.7.4.9. -!- Formerly EC 2.7.1.75.

UniProtKB Entries (1)

P03176
KITH_HHV11
Human alphaherpesvirus 1 strain 17
Thymidine kinase

PDB Structure

PDB 1KI4
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands.
Champness, J.N., Bennett, M.S., Wien, F., Visse, R., Summers, W.C., Herdewijn, P., de Clerq, E., Ostrowski, T., Jarvest, R.L., Sanderson, M.R.
Proteins